English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/49272
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Altered arachidonate distribution in macrophages from caveolin-1 null mice leading to a reduced eicosanoid synthesis

AuthorsAstudillo, Alma M. CSIC ORCID; Pérez-Chacón, Gema CSIC ORCID; Meana, Clara CSIC ORCID; Balgoma, David CSIC; Pol, Albert; Pozo, Miguel A. del; Balboa, María A. CSIC ORCID; Balsinde, Jesús CSIC ORCID
Issue DateOct-2011
PublisherAmerican Society for Biochemistry and Molecular Biology
CitationJournal of Biological Chemistry 286(40): 35299-35307 (2011)
AbstractIn this work we have studied the effect of caveolin-1 deficiency on the mechanisms that regulate free arachidonic acid (AA) availability. Results presented here demonstrate that macrophages from caveolin-1-deficient mice exhibit elevated fatty acid incorporation and remodeling and a constitutively increased CoA-independent transacylase activity. Mass spectrometry-based lipidomic analyses reveal stable alterations in the profile of AA distribution among phospholipids, manifested by reduced levels of AA in choline glycerophospholipids but elevated levels in ethanolamine glycerophospholipids and phosphatidylinositol. Furthermore, macrophages from caveolin-1 null mice show decreased AA mobilization and PGE 2 and LTB4 production upon cell stimulation. Collectively, these results provide insight into the role of caveolin-1 in AA homeostasis and suggest an important role for this protein in the eicosanoid biosynthetic response.
Description20 páginas, 7 figuras, 1 tabla.-- El pdf del artículo es la versión post-print.
Publisher version (URL)http://dx.doi.org/10.1074/jbc.M111.277137
Appears in Collections:(IBGM) Artículos
Files in This Item:
File Description SizeFormat 
Altered Arachidonate.pdf132,01 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.