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Título: | Altered arachidonate distribution in macrophages from caveolin-1 null mice leading to a reduced eicosanoid synthesis |
Autor: | Astudillo, Alma M. CSIC ORCID; Pérez-Chacón, Gema CSIC ORCID; Meana, Clara CSIC ORCID; Balgoma, David CSIC ORCID; Pol, Albert; Pozo, Miguel A. del; Balboa, María A. CSIC ORCID; Balsinde, Jesús CSIC ORCID | Fecha de publicación: | oct-2011 | Editor: | American Society for Biochemistry and Molecular Biology | Citación: | Journal of Biological Chemistry 286(40): 35299-35307 (2011) | Resumen: | In this work we have studied the effect of caveolin-1 deficiency on the mechanisms that regulate free arachidonic acid (AA) availability. Results presented here demonstrate that macrophages from caveolin-1-deficient mice exhibit elevated fatty acid incorporation and remodeling and a constitutively increased CoA-independent transacylase activity. Mass spectrometry-based lipidomic analyses reveal stable alterations in the profile of AA distribution among phospholipids, manifested by reduced levels of AA in choline glycerophospholipids but elevated levels in ethanolamine glycerophospholipids and phosphatidylinositol. Furthermore, macrophages from caveolin-1 null mice show decreased AA mobilization and PGE 2 and LTB4 production upon cell stimulation. Collectively, these results provide insight into the role of caveolin-1 in AA homeostasis and suggest an important role for this protein in the eicosanoid biosynthetic response. | Descripción: | 20 páginas, 7 figuras, 1 tabla.-- El pdf del artículo es la versión post-print. | Versión del editor: | http://dx.doi.org/10.1074/jbc.M111.277137 | URI: | http://hdl.handle.net/10261/49272 | DOI: | 10.1074/jbc.M111.277137 | ISSN: | 0021-9258 | E-ISSN: | 1083-351X |
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Altered Arachidonate.pdf | 132,01 kB | Adobe PDF | Visualizar/Abrir |
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