English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/4926
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

HIV-1 protease inhibitors: effects on HIV-2 replication and resistance

AutorMenéndez-Arias, Luis ; Tözsér, József
Palabras claveHIV-1
HIV-2
Fecha de publicación4-dic-2007
EditorElsevier
CitaciónTrends in Pharmacological Sciences Vol. 29, Issue 1, January 2008, Pages 42-49
ResumenNovel antiretroviral drugs include protease (PR) inhibitors (e.g. atazanavir, tipranavir and darunavir) that block HIV-1 maturation and show remarkable antiviral potency on drug-resistant isolates. However, the strains used as prototypes in the design of the novel drugs belong to a specific clade (i.e. HIV-1 group M subtype B), which is the most prevalent in developed countries. At the same time, there is an increasing concern about the expansion of other HIV-1 clades as well as other related retroviruses, such as HIV-2. The HIV-2 PR is weakly inhibited by some PR inhibitors (e.g. amprenavir), and little is known of the mutational pathways leading to drug resistance in this virus. The design of specific PR inhibitors targeting HIV-2, or potent drugs showing broad specificity on HIV-1 and HIV-2 clades, remains a major challenge for the future
Versión del editorhttp://dx.doi.org/10.1016/j.tips.2007.10.013
URIhttp://hdl.handle.net/10261/4926
DOI10.1016/j.tips.2007.10.013
ISSN0165-6147 (Print)
1873-3735 (Online)
Aparece en las colecciones: (CBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
LMenendez_TIPS_42.pdf470,21 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.