Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/49235
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Juganaru, Maria Magdalena | - |
dc.contributor.author | Reina, Ramsés | - |
dc.contributor.author | Bertolotti, Luigi | - |
dc.contributor.author | Stella, Maria Cristina | - |
dc.contributor.author | Profiti, Margherita | - |
dc.contributor.author | Armentano, María G. | - |
dc.contributor.author | Bollo, Enrico | - |
dc.contributor.author | Amorena Zabalza, Beatriz | - |
dc.contributor.author | Rosati, Sergio | - |
dc.date.accessioned | 2012-05-04T12:03:41Z | - |
dc.date.available | 2012-05-04T12:03:41Z | - |
dc.date.issued | 2011-02 | - |
dc.identifier.citation | Virology 410(1): 88-95 (2011) | es_ES |
dc.identifier.issn | 0924-8579 | - |
dc.identifier.uri | http://hdl.handle.net/10261/49235 | - |
dc.description | 8 p., 6 figures, 1 table and references | es_ES |
dc.description.abstract | Small ruminant lentivirus genotype E lacks the dUTPase subunit and vpr-like gene. Two strains (Roccaverano and Seui) with identical genetic organization have been described, with the env HV1–HV2 domains being the most divergent. Although dUTPase and vpr-like deletions have been involved in the RT fidelity in non dividing cells, both strains were able to replicate efficiently in blood derived macrophages (BDM), while virus production of E1 subtype was reduced or abrogated in replicating fibroblastic-like cells. The transcriptional activity of genotype E was similar in these two cellular populations. When viral pseudotypes were generated with the env of both viruses, Roccaverano pseudotype displayed a paranuclear localization on BDM, suggesting a different mechanism of entry. Polymorphic GAS and TAS sites in the U3 region, further suggest that a population different from classically activated macrophages can be infected by these viruses, opening new insights into lentiviruses with low or null pathogenic potential. | es_ES |
dc.description.sponsorship | This work was supported by Regione Piemonte, Ricerca Sanitaria Finalizzata 2009. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Academic Press | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Small ruminant lentivirus | es_ES |
dc.subject | Genotype E | es_ES |
dc.subject | dUTPase | es_ES |
dc.subject | vpr-like | es_ES |
dc.subject | Viral pseudotype | es_ES |
dc.subject | Entry assay | es_ES |
dc.title | In vitro properties of small ruminant lentivirus genotype E | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.virol.2010.10.031 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.virol.2010.10.031 | es_ES |
dc.identifier.e-issn | 1872-7913 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (IDAB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
restringido.pdf | 21,67 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
16
checked on 13-abr-2024
WEB OF SCIENCETM
Citations
16
checked on 24-feb-2024
Page view(s)
382
checked on 23-abr-2024
Download(s)
194
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.