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Título : Cyclooxygenase 2: understanding the pathophysiological role through genetically altered mouse models
Autor : Martín-Sanz, Paloma ; Hortelano, Sonsoles; Boscá, Lisardo ; Casado, Marta
Palabras clave : Cyclooxygenase
Prostanoids
Fecha de publicación : 1-sep-2006
Editor: Frontiers in Bioscience Publications
Citación : Frontiers in Bioscience 11: 2876-2878 (2006)
Resumen: Cyclooxygenase (COX) -1 and –2 catalyze the first step in the biosynthesis of prostanoids. COX-1 is constitutively expressed in many tissues and seems to be involved in the house keeping function of prostanoids. COX-2, the inducible isoform, accounts for the elevated production of prostaglandins in response to various inflammatory stimuli, hormones and growth factors. COX-2 expression has been also associated with cell growth regulation, tissue remodelling and carcinogenesis. More of these characteristics have been elucidate through using COX selective inhibitors. Recent advances in transgenic and gene-targeting approaches allow a sophisticated manipulation of the mouse genome by gene addition, gene deletion or gene modifications. The development of COX-2 genetically altered mice has provided models to elucidate the physiological and pathophysiological roles of this enzyme.
Descripción : El pdf del artículo es la versión post-print.
Versión del editor: http://dx.doi.org/10.2741/2016
URI : http://hdl.handle.net/10261/4903
DOI: 10.2741/2016
ISSN: 1093-9946
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