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Title

Cyclooxygenase 2: understanding the pathophysiological role through genetically altered mouse models

AuthorsMartín-Sanz, Paloma ; Hortelano, Sonsoles; Boscá, Lisardo ; Casado, Marta
KeywordsCyclooxygenase
Prostanoids
Issue Date1-Sep-2006
PublisherFrontiers in Bioscience Publications
CitationFrontiers in Bioscience 11: 2876-2878 (2006)
AbstractCyclooxygenase (COX) -1 and –2 catalyze the first step in the biosynthesis of prostanoids. COX-1 is constitutively expressed in many tissues and seems to be involved in the house keeping function of prostanoids. COX-2, the inducible isoform, accounts for the elevated production of prostaglandins in response to various inflammatory stimuli, hormones and growth factors. COX-2 expression has been also associated with cell growth regulation, tissue remodelling and carcinogenesis. More of these characteristics have been elucidate through using COX selective inhibitors. Recent advances in transgenic and gene-targeting approaches allow a sophisticated manipulation of the mouse genome by gene addition, gene deletion or gene modifications. The development of COX-2 genetically altered mice has provided models to elucidate the physiological and pathophysiological roles of this enzyme.
DescriptionEl pdf del artículo es la versión post-print.
Publisher version (URL)http://dx.doi.org/10.2741/2016
URIhttp://hdl.handle.net/10261/4903
DOI10.2741/2016
ISSN1093-9946
Appears in Collections:(IBV) Artículos
(CIB) Artículos
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