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dc.contributor.authorOrtiz-Delgado, Juan B.-
dc.contributor.authorSegner, Helmut-
dc.contributor.authorArellano, Juana M.-
dc.contributor.authorSarasquete, Carmen-
dc.date.accessioned2012-04-26T09:52:20Z-
dc.date.available2012-04-26T09:52:20Z-
dc.date.issued2007-
dc.identifier.citationHistology and Histopathology (Cellular and Molecular Biology ) 22(4): 417-432 (2007)es_ES
dc.identifier.issn0213-3911-
dc.identifier.urihttp://hdl.handle.net/10261/49028-
dc.description16 páginas, 9 figuras, 4 tablas.es_ES
dc.description.abstractThis study compared for seabream, Sparus aurata exposed to benzo(a)pyrene-B(a)P-, the response of molecular cytochrome P450 1A (CYP1A) and cellular histopathology biomarkers. Male gilthead seabream, Sparus aurata specimens were exposed for 20 days via water to a series of high B(a)P concentrations. CYP1A was assessed by measuring enzymatic activity (EROD) and CYP1A protein content, and cellular responses were evaluated by routine histopathological methods. In addition, biliary metabolites were measured in order to verify that B(a)P was absorbed and metabolised. Histological lesions, both in liver and gills, increased in parallel to B(a)P concentrations, with the majority of changes representing rather non-specific alterations. Hepatic EROD and CYP1A proteins data showed a concentration-dependent induction, while in the gills, EROD activity but not CYP1A proteins showed a non-monotonous dose response, with a maximum induction level at 200 µg B(a)P.L-1 and decreasing levels thereafter. The findings provide evidence that short-term, high dose exposure of fish can result in significant uptake and metabolism of the lipophilic B(a)P, and in pronounced pathological damage of absorptive epithelia and internal organs.es_ES
dc.description.sponsorshipThis work was supported (project HA1998-08) by Spanish Science and Technology Inter Ministery Commission (CYCYT) (ICMAN. CSIC, Spain) and German Academic Exchange Service, DADD (UFZ, Germany).es_ES
dc.language.isoenges_ES
dc.publisherUniversidad de Murciaes_ES
dc.rightsopenAccesses_ES
dc.subjectB(a)Pes_ES
dc.subjectLiveres_ES
dc.subjectGillses_ES
dc.subjectHistopathologyes_ES
dc.subjectCYP1Aes_ES
dc.subjectBiliary metaboliteses_ES
dc.subjectSparus aurataes_ES
dc.titleHistopathological alterations, EROD activity, CYP1A protein and biliary metabolites in gilthead seabream Sparus aurata exposed to Benzo(a)pyrenees_ES
dc.typeartículoes_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://www.hh.um.es/Abstracts/Vol_22/22_4/22_4_417.htmes_ES
dc.identifier.e-issn1699-5848-
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