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dc.contributor.authorSardanyés, Josep-
dc.contributor.authorMartínez, Fernando-
dc.contributor.authorDaròs Arnau, José Antonio-
dc.contributor.authorElena, Santiago F.-
dc.date.accessioned2012-04-24T10:47:10Z-
dc.date.available2012-04-24T10:47:10Z-
dc.date.issued2012-04-07-
dc.identifier.citationJournal of the Royal Society Interface 9/69:768-776 (2012)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/48825-
dc.description.abstractWe propose and study nonlinear mathematical models describing the intracellular time dynamics of viral RNA accumulation for positive sense single-stranded RNA viruses. Our models consider different replication modes ranging between two extremes represented by the geometric replication (GR) and the linear stamping machine replication (SMR). We first analyze a model that quantitatively reproduced experimental data for the accumulation dynamics of both polarities of Turnip mosaic potyvirus RNAs. We identify a non-degenerate transcritical bifurcation governing the extinction of both strands depending on three key parameters: the mode of replication (®), the replication rate (r) and the degradation rate (±) of viral strands. Our results indicate that the bifurcation associated with ® generically takes place when the replication mode is closer to the SMR, thus suggesting that GR may provide viral strands with an increased robustness against degradation. This transcritical bifurcation, which is responsible for the switching from an active to an absorbing regime, suggests a smooth (i.e., second-order), absorbing-state phase transition. Finally, we also analyze a simplified model that only incorporates asymmetry in replication tied to differential replication modes.es_ES
dc.description.sponsorshipThis work has been funded by the Human Frontier Science Program Organization grant RGP12/2008, by the Spanish Ministerio de Ciencia e Innovaci´on grants BIO2008-01986 (JAD) and BFU2009-06993 (SFE), and by the Santa Fe Institute. FM is the recipient of a predoctoral fellowship from Universitat Polit`ecnica de Val`encia. We also want to thank the hospitality and support of the Kavli Institute for Theoretical Physics (University of California at Santa Barbara), where part of this work was developed (grant NSF PHY05-51164).es_ES
dc.language.isoenges_ES
dc.publisherRoyal Society (Great Britain)es_ES
dc.rightsopenAccesses_ES
dc.subjectComplex systemses_ES
dc.subjectIntracellular viral dynamicses_ES
dc.subjectNonlinear dynamicses_ES
dc.subjectReplication modees_ES
dc.titleDynamics of alternative modes of RNA replication for positive-sense RNA viruseses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1098/rsif.2011.0471-
dc.description.peerreviewedPeer reviewedes_ES
dc.identifier.e-issn1742-5689-
dc.identifier.pmid21900320-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
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