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Title

Luria-Delbrück Estimation of Turnip mosaic virus Mutation Rate in vivo

AuthorsIglesia, Francisca de la ; Martínez, Fernando ; Hillung, Julia ; Cuevas, José M. ; Gerrish, Philip J.; Daròs Arnau, José Antonio ; Elena, Santiago F.
KeywordsPlant RNA virus
Interference
Replication
Resistance
Issue DateMar-2012
PublisherAmerican Society for Microbiology
CitationJournal of Virology 86/6:3386-3388 (2012)
AbstractA potential drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs is the ease with which viruses may generate escape mutations. Using a variation of the classic Luria-Delbrück fluctuation assay, we estimated that the spontaneous mutation rate in the artificial microRNA (amiR) target of a plant virus was ca. 6×10−5 per replication event.
URIhttp://hdl.handle.net/10261/48822
DOI10.1128/​JVI.06909-11
E-ISSN0022-538X
Appears in Collections:(IBMCP) Artículos
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