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Título

RNAs: regulators of bacterial virulence

AutorGripenland, Jonas; Netterling, Sakura; Loh, Edmund; Tiensuu, Teresa; Toledo-Arana, Alejandro ; Johansson, Jörgen
Fecha de publicacióndic-2010
EditorNature Publishing Group
CitaciónNature Reviews Microbiology 8(12): 857-866 (2010)
ResumenRNA-based pathways that regulate protein expression are much more widespread than previously thought. Regulatory RNAs, including 5′ and 3′ untranslated regions next to the coding sequence, cis-acting antisense RNAs and trans-acting small non-coding RNAs, are effective regulatory molecules that can influence protein expression and function in response to external cues such as temperature, pH and levels of metabolites. This Review discusses the mechanisms by which these regulatory RNAs, together with accessory proteins such as RNases, control the fate of mRNAs and proteins and how this regulation influences virulence in pathogenic bacteria.
Descripción10 p., 4 figures and bibliography
Versión del editorhttp://dx.doi.org/10.1038/nrmicro2457
URIhttp://hdl.handle.net/10261/48618
DOI10.1038/nrmicro2457
ISSN1740-1526
E-ISSN1740-1534
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