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Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs

AuthorsSantiago, Julia ; Dupeux, Florine; Betz, Katja; Antoni, Regina ; González-Guzmán, Miguel; Rodríguez, Lesia ; Márquez, José Antonio; Rodríguez, Pedro L.
KeywordsProtein phosphatase 2C
Negative regulator
Issue DateJan-2012
CitationPlant Science 182:3-11 (2012)
AbstractAbscisic acid (ABA) plays an essential function in plant physiology since it is required for biotic and abiotic stress responses as well as control of plant growth and development. A new family of soluble ABA receptors, named PYR/PYL/RCAR, has emerged as ABA sensors able to inhibit the activity of specific protein phosphatases type-2C (PP2Cs) in an ABAdependent manner. The structural and functional mechanism by which ABA is perceived by these receptors and consequently leads to inhibition of the PP2Cs has been recently elucidated. The module PYR/PYL/RCARABA- PP2C offers an elegant and unprecedented mechanism to control phosphorylation signaling cascades in a ligand-dependent manner. The knowledge of their three-dimensional structures paves the way to the design of ABA agonists able to modulate the plant stress response.
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