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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/48424
Título

Invasive Cell Behavior during Drosophila Imaginal Disc Eversion Is Mediated by the JNK Signaling Cascade

AutorPastor-Pareja, José Carlos; Grawe, Ferdinand; Martín-Blanco, Enrique ; García-Bellido, Antonio
Palabras claveDrosophila
Larvae
Imaginal
Disc
Exoskeleton
PEMT
Fecha de publicaciónsep-2004
EditorCell Press
CitaciónDevelopmental Cell 7 (3): 387–399 (2204)
ResumenDrosophila imaginal discs are monolayered epithelial invaginations that grow during larval stages and evert at metamorphosis to assemble the adult exoskeleton. They consist of columnar cells, forming the imaginal epithelium, as well as squamous cells, which constitute the peripodial epithelium and stalk (PS). Here, we uncover a new morphogenetic/cellular mechanism for disc eversion. We show that imaginal discs evert by apposing their peripodial side to the larval epidermis and through the invasion of the larval epidermis by PS cells, which undergo a pseudo-epithelial-mesenchymal transition (PEMT). As a consequence, the PS/larval bilayer is perforated and the imaginal epithelia protrude, a process reminiscent of other developmental events, such as epithelial perforation in chordates. When eversion is completed, PS cells localize to the leading front, heading disc expansion. We found that the JNK pathway is necessary for PS/larval cells apposition, the PEMT, and the motile activity of leading front cells.
Versión del editorhttp://dx.doi.org/10.1016/j.devcel.2004.07.022
URIhttp://hdl.handle.net/10261/48424
DOI10.1016/j.devcel.2004.07.022
ISSN1534-5807
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