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The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing

AutorFernández-Fúnez, P.; Cheng-Hsin, Lu; Rincón-Limas, Diego; García-Bellido, Antonio ; Botas, J.
Palabras claveApterous
Co-factor
Compartment
LDB
LIM domain
Drosophila
Fecha de publicación1998
EditorMacmillan Publishers
CitaciónEMBO Journal 17: 6846 - 6853 (1998)
ResumenDorso-ventral axis formation in the Drosophila wing requires the localized accumulation of the Apterous LIM/homeodomain protein (Ap) in dorsal cells. Here we report that dLdb/Chip encodes a LIM-binding cofactor that controls Ap activity. Both lack and excess of dLdb/Chip function cause the same phenotype as apterous (ap) lack of function; i.e. dorsal to ventral transformations, generation of new wing margins, and wing outgrowths. These results indicate that the normal function of Ap in dorso-ventral compartmentalization requires the correct amount of the DLDB/CHIP co-factor, and suggest that the Ap and DLDB/CHIP proteins form a multimeric functional complex. In support of this model, we show that the dLdb/Chip excess-of-function phenotypes can be rescued by ap overexpression.
Versión del editorhttp://dx.doi.org/10.1093/emboj/17.23.6846
URIhttp://hdl.handle.net/10261/48343
DOI10.1093/emboj/17.23.6846
ISSN0261-4189
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