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dc.contributor.authorCuezva, José M.-
dc.contributor.authorSánchez-Aragó, María-
dc.contributor.authorSala, Sandra-
dc.contributor.authorBlanco-Rivero, Amaya-
dc.contributor.authorOrtega, Álvaro D.-
dc.date.accessioned2008-06-05T14:23:01Z-
dc.date.available2008-06-05T14:23:01Z-
dc.date.issued2007-08-28-
dc.identifier.citationJournal of Bioenergetics & Biomembranes Vol.39 (3) 259-265 (2007)en_US
dc.identifier.issn0145-479X (Print)-
dc.identifier.issn1573-6881 (Online)-
dc.identifier.urihttp://hdl.handle.net/10261/4822-
dc.descriptionThe original publication is available at www.springerlink.com http://dx.doi.org/10.1007/s10863-007-9087-9en_US
dc.description.abstractMitochondrial research has experienced a considerable boost during the last decade because organelle malfunctioning is in the genesis and/or progression of a vast array of human pathologies including cancer. The renaissance of mitochondria in the cancer field has been promoted by two main facts: (1) the molecular and functional integration of mitochondrial bioenergetics with the execution of cell death and (2) the implementation of 18FDG-PET for imaging and staging of tumors in clinical practice. The latter, represents the bed-side translational development of the metabolic hallmark that describes the bioenergetic phenotype of most cancer cells as originally predicted at the beginning of previous century by Otto Warburg. In this minireview we will briefly summarize how the study of energy metabolism during liver development forced our encounter with Warburg’s postulates and prompted us to study the mechanisms that regulate the biogenesis of mitochondria in the cancer cellen_US
dc.description.sponsorshipThis review article was written while the research activity in the authors’ laboratory was supported by grants from the Ministerio de Sanidad (PI041255), Educación y Ciencia (SAF2005-4001) and Fundación Mutua Madrileña. The CBMSO is the recipient of an institutional grant from Fundación Ramón Arecesen_US
dc.format.extent228887 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsopenAccessen_US
dc.subjectMitochondriaen_US
dc.subjectH+-ATP synthaseen_US
dc.subjectOxidative phosphorylationen_US
dc.subjectGlycolysisen_US
dc.subjectCanceren_US
dc.titleA message emerging from development: the repression of mitochondrial β-F1-ATPase expression in canceren_US
dc.typeArtículoen_US
dc.description.peerreviewedPeer revieweden_US
dc.contributor.funderMinisterio de Sanidad y Consumo (España)-
dc.contributor.funderMinisterio de Educación y Ciencia (España)-
dc.contributor.funderFundación Mutua Madrileña-
dc.contributor.funderFundación Ramón Areces-
dc.identifier.funderhttp://dx.doi.org/10.13039/100008061es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100008054es_ES
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