English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/48165
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorMalakoutikhah, Morteza-
dc.contributor.authorGómara Elena, María José-
dc.contributor.authorGómez-Puerta, José A.-
dc.contributor.authorSanmartí, Raimon-
dc.contributor.authorHaro Villar, Isabel-
dc.date.accessioned2012-04-12T09:41:32Z-
dc.date.available2012-04-12T09:41:32Z-
dc.date.issued2011-
dc.identifier.citationJournal of Medicinal Chemistryes_ES
dc.identifier.issn0022-2623-
dc.identifier.urihttp://hdl.handle.net/10261/48165-
dc.description.abstractRheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and, in many cases, destruction of the joints. To prevent progressive and irreversible structural damage, early diagnosis of RA is of paramount importance. The present study addresses the search of new RA citrullinated antigens that could supplement or complement diagnostic/prognostic existing tests. With this aim, the epitope anticitrullinated vimentin antibody response was mapped using synthetic peptides. To improve the sensitivity/specificity balance, a vimentin peptide that was selected, and its cyclic analogue, were combined with fibrin- and filaggrin-related peptides to render chimeric peptides. Our findings highlight the putative application of these chimeric peptides for the design of RA diagnosis systems and imply that more than one serological test is required to classify RA patients based on the presence or absence of ACPAs. Each of the target molecules reported here (fibrin, vimentin, filaggrin) has a specific utility in the identification of a particular subset of RA patients.es_ES
dc.description.sponsorshipThis work has been partially funded by Grant FIS PI080207 from the Instituto de Salud Carlos III, Ministry of Science and Innovation, Spain.-
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.rightsclosedAccesses_ES
dc.titleThe Use of Chimeric Vimentin Citrullinated Peptides for the Diagnosis of Rheumatoid Arthritises_ES
dc.typeartículoes_ES
dc.identifier.doi10.1021/jm200563u-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1021/jm200563ues_ES
dc.identifier.e-issn1520-4804-
Appears in Collections:(IQAC) Artículos
Files in This Item:
There are no files associated with this item.
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.