English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/48090
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Effect of the temperature during antiviral immune response ontogeny in teleosts

AutorDios, S. ; Romero, Alejandro ; Chamorro, Rubén ; Figueras Huerta, Antonio ; Novoa, Beatriz
Palabras claveInnate immunity
Temperature
Ontogeny
Antiviral
Poly I:C
VHSV
Fecha de publicación2010
EditorElsevier
CitaciónShell and Shellfish Immunology 29(6): 1019-1027 (2010)
ResumenZebrafish were used to investigate the expression levels of several antiviral and inflammatory genes (IL-1β, iNOS, TNF-α, TLR3, IFN-I, IFNγ, IRF3, MDA-5, Mx) constitutively and after viral stimulation during early development. We also determined how their expression was affected by changes in the temperature. The antiviral genes were almost completely inhibited at 15 °C with the exception of TLR3. In contrast, IL-1β, iNOS and TNF-α expression was not obviously different between the two temperatures. At 15 °C, most of the genes examined did not differ following stimulation with poly I:C or viral hemorrhagic septicemia virus (VHSV). However, at 28 °C, all of the genes showed significant differences in at least some of the sampling points after poly I:C treatment with the largest differences observed for Mx. Mx expression in adult zebrafish was not significantly altered by temperature and poly I:C treatment led to a smaller increase in gene expression when compared to larval Mx levels. Thus, Mx seems to play an important role in viral immunity in larvae, when the adaptive immune response is not fully functional
Descripción1 tabla, 6 figuras
Versión del editorhttp://dx.doi.org/10.1016/j.fsi.2010.08.006
URIhttp://hdl.handle.net/10261/48090
DOI10.1016/j.fsi.2010.08.006
ISSN1050-4648
E-ISSN1095-9947
Aparece en las colecciones: (IIM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Dios et al_Teleost_2010_Revised_final.pdf418,05 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.