English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/48088
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

NKT TCR Recognition of CD1d-α-C-Galactosylceramide

AutorPatel, Onisha; Cameron, Garth; Pellicci, Daniel G.; Liu, Zheng; Byun, Hoe-Sup; Beddoe, Travis; McCluskey, James; Franck, Richard W.; Castaño, A. Raúl; Harrak Serifi, Youssef; Llebaria, Amadeu; Bittman, Robert; Porcelli, Steven A.; Godfrey, Dale I.; Rossjohn, Jamie
Fecha de publicación2011
EditorAmerican Association of Immunologists
CitaciónJournal of Immunology
ResumenNKT cells respond to a variety of CD1d-restricted glycolipid Ags that are structurally related to the prototypic Ag α-galactosylceramide (α-GalCer). A modified analog of α-GalCer with a carbon-based glycosidic linkage (α-C-GalCer) has generated great interest because of its apparent ability to promote prolonged, Th1-biased immune responses. In this study, we report the activation of spleen NKT cells to α-C-GalCer, and related C-glycoside ligands, is weaker than that of α-GalCer. Furthermore, the Vβ8.2 and Vβ7 NKT TCR affinity for CD1d–α-C-GalCer, and some related analogs, is ∼10-fold lower than that for the NKT TCR–CD1d–α-GalCer interaction. Nevertheless, the crystal structure of the Vβ8.2 NKT TCR–CD1d–α-C-GalCer complex is similar to that of the corresponding NKT TCR–CD1d–α-GalCer complex, although subtle differences at the interface provide a basis for understanding the lower affinity of the NKT TCR–CD1d–α-C-GalCer interaction. Our findings support the concept that for CD1d-restricted NKT cells, altered glycolipid ligands can promote markedly different responses while adopting similar TCR-docking topologies.
Versión del editorhttp://dx.doi.org/10.4049/jimmunol.1100794
URIhttp://hdl.handle.net/10261/48088
DOI10.4049/jimmunol.1100794
ISSN0022-1767
E-ISSN1550-6606
Aparece en las colecciones: (IQAC) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.