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dc.contributor.authorGracheva, M. E.-
dc.contributor.authorToral, Raúl-
dc.contributor.authorGunton, James D.-
dc.date.accessioned2012-04-09T10:15:06Z-
dc.date.available2012-04-09T10:15:06Z-
dc.date.issued2002-02-28-
dc.identifier.citationJournal of Theoretical Biology 212: 111 (2001)es_ES
dc.identifier.issn0022-5193-
dc.identifier.urihttp://hdl.handle.net/10261/47985-
dc.descriptionTexto completo borrador de autor.-
dc.description.abstractWe carry out a Monte Carlo simulation of stochastic effects for two models of intercellular calcium wave propagation in rat hepatocytes. Both models involve gap junction diffusion by a second messenger. We find that, in general, the stochastic effects improve agreement with experiment, for a reasonable choice of model parameters. Both stochastic models exhibit baseline fluctuations and variations in the peak heights of Ca2+. In addition, we find for one model that there is a distribution of latency times, rather than a single latency time, with a distribution width which is comparable to the experimental observation of spike widths. We also find for the other model with low gap junction diffusion that it is possible for cell multiplets to oscillate independently initially, but to subsequently become synchronized.es_ES
dc.description.sponsorshipThis work was supported in part by NSF Grant number DMR9813409 and the DGES (Spain) projects PB97-0141-C02-01 and BFM2000-1108.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsopenAccesses_ES
dc.subjectStochastic-
dc.subjectCalcium waves-
dc.subjectCalcium signaling-
dc.titleStochastic effects in intercellular calcium spiking in hepatocyteses_ES
dc.typeArtículoes_ES
dc.identifier.doi10.1006/jtbi.2001.2362-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1006/jtbi.2001.2362es_ES
dc.identifier.e-issn1095-8541-
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