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Formation of knots in partially replicated DNA molecules

AuthorsSogo, José; Stasiak, Andrzej Z.; Martínez-Robles, María Luisa ; Krimer, Dora B. ; Hernandez, Pablo ; Schvartzman, Jorge Bernardo
KeywordsDNA replication
DNA knotting
DNA topology
ColE1 origin of replication
Issue Date1999
PublisherAcademic Press
CitationJ. Mol. Biol. 286(3):637-643(1999)
AbstractBacterial plasmids with two origins of replication in convergent orientation are frequently knotted in vivo. The knots formed are localised within the newly replicated DNA regions. Here, we analyse DNA knots tied within replication bubbles of such plasmids, and observe that the knots formed show predominantly positive signs of crossings. We propose that helical winding of replication bubbles in vivo leads to topoisomerase-mediated formation of knots on partially replicated DNA molecules. (C) 1999 Academic Press.
Description7 páginas, 4 figuras, -- PAGS nros.637-643
Publisher version (URL)http://dx.doi.org/10.1006/jmbi.1998.2510
Appears in Collections:(CIB) Artículos
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