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dc.contributor.authorSanjuán, Rafael-
dc.contributor.authorCuevas, José M.-
dc.contributor.authorFurió, Victoria-
dc.contributor.authorHolmes, Edward C.-
dc.contributor.authorMoya-Simarro, Andrés-
dc.identifier.citationPLoS Genetics 3/6:e93 (2007)es_ES
dc.description.abstractMutational robustness is defined as the constancy of a phenotype in the face of deleterious mutations. Whether robustness can be directly favored by natural selection remains controversial. Theory and in silico experiments predict that, at high mutation rates, slow-replicating genotypes can potentially outcompete faster counterparts if they benefit from a higher robustness. Here, we experimentally validate this hypothesis, dubbed the ‘‘survival of the flattest,’’ using two populations of the vesicular stomatitis RNA virus. Characterization of fitness distributions and genetic variability indicated that one population showed a higher replication rate, whereas the other was more robust to mutation. The faster replicator outgrew its robust counterpart in standard competition assays, but the outcome was reversed in the presence of chemical mutagens. These results show that selection can directly favor mutational robustness and reveal a novel viral resistance mechanism against treatment by lethal mutagenesis.es_ES
dc.description.sponsorshipThis study was financially supported by grants from the Spanish Generalitat Valenciana (grant GV06/031) to RS, the Wellcome Trust (grant 071979) to AM and ECH, and the Spanish Ministerio de Educacio´n y Ciencia (grant BFU2005–00305) to AM. RS was funded by the Spanish Ministerio de Educacio´n y Ciencia and Consejo Superior de Investigaciones Cientı´ficas. JMC was funded by the Wellcome Trust. VF was funded by the Spanish Ministerio de Educacio´n y Ciencia.es_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation.isversionofPublisher’s version-
dc.titleSelection for Robustness in Mutagenized RNA Viruseses_ES
dc.identifier.doidoi:10.1371/journal.pgen. 0030093-
dc.description.peerreviewedPeer reviewedes_ES
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