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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Servili, Arianna | - |
dc.contributor.author | Le Page, Yann | - |
dc.contributor.author | Leprince, Jérôme | - |
dc.contributor.author | Caraty, Alain | - |
dc.contributor.author | Escobar, Sebastián | - |
dc.contributor.author | Parhar, Ishwar S. | - |
dc.contributor.author | Seong, Jae Yong | - |
dc.contributor.author | Vaudry, Hubert | - |
dc.contributor.author | Kah, Olivier | - |
dc.date.accessioned | 2012-04-03T09:48:07Z | - |
dc.date.available | 2012-04-03T09:48:07Z | - |
dc.date.issued | 2011-04 | - |
dc.identifier.citation | Endocrinology 152(4): 1527-1540 (2011) | es_ES |
dc.identifier.issn | 0013-7227 | - |
dc.identifier.uri | http://hdl.handle.net/10261/47870 | - |
dc.description | 14 p., 1 table, 8 figures and bibliography | es_ES |
dc.description.abstract | Kisspeptins are new actors in the neuroendocrine regulation of reproduction. In vertebrates, the number of kiss genes varies from none to three. Zebrafish have two kiss genes, kiss1 and kiss2, and two kiss receptors (GPR54), kiss1r and kiss2r. To provide detailed information on the organization of the kiss systems in zebrafish, antibodies were raised against the C terminus of zebrafish preproKiss1 and preproKiss2. Immunohistochemistry fully confirmed in situ hybridization data, showing that kiss1-expressing neurons are only located in the habenular nucleus, while kiss2-expressing neurons are found in the dorsal and ventral hypothalamus. Kiss1-expressing cells project only to the interpeduncular and raphe nuclei and strongly expressed the kiss1r receptor. In contrast, kiss2-expressing cells are mostly present in the dorsal and ventral hypothalamus and project widely into the subpallium, the preoptic area, the thalamus, the ventral and caudal hypothalamus, and the mesencephalon. All these regions strongly expressed the kiss2r messengers. Kiss2 fibers profusely innervate the ventral forebrain and notably made close apposition with GnRH3 neurons. Estrogen treatment of juvenile fish with estradiol causes increase in kiss2 and kiss2r expression. In the pituitary gland, no proKiss2-positive fibers were detected, while positive cells were observed in the pars intermedia. In addition to proposing a successful strategy to develop antibodies to kisspeptins, these data indicate that the kiss2 systems of zebrafish are implicated in reproductive events, while the kiss1 gene would play other functions that remain to be established. | es_ES |
dc.description.sponsorship | This work was supported by European project No. 222719 (LIFECYCLE to O.K.), the Agence Nationale de la Recherche NEED (CES 2008-011 to O.K.), the Post-Grenelle de l’Environnement (NEMO to O.K.), the Agence Nationale de la Recherche French Kiss (to J.L., A.C., and H.V.), and a French-Korean exchange program (STAR to J.Y.S. and H.V.). A.S. and Y.L.P. were supported by postdoctoral fellowships from the European Union and the Agence Nationale de la Recherche, respectively. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Endocrine Society | es_ES |
dc.rights | openAccess | es_ES |
dc.title | Organization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1210/en.2010-0948 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1210/en.2010-0948 | es_ES |
dc.identifier.e-issn | 1945-7170 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Organization of two independent kisspeptin.pdf | 4,16 MB | Adobe PDF | Visualizar/Abrir |
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