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Positive and negative cis-regulatory elements in the bithoraxoid region of the Drosophila Ultrabithorax gene

AuthorsCastelli-Gair Hombría, James ; Capdevila, M. P.; Micol, J. L.; García-Bellido, Antonio
Spatial gene control
Issue Date1992
CitationMolecular and General Genetics MGG 234 (2): 177-184 (1992)
AbstractThe Ultrabithorax (Ubx) gene is required during embryogenesis and larval development to specify the third thoracic and first abdominal segments of Drosophila melanogaster. Mutations in the bithoraxoid (bxd) region, a 40 kb DNA stretch upstream of the Ubx promoter, affect cis-regulatory elements responsible for the ectodermal expression of the Ubx gene in the posterior compartment of the third thoracic segment and anterior compartment of the first abdominal segment. Our genetic data and the available molecular information are used to map the adult epidermal cis-regulatory elements within the bxd region. Genetic combinations involving mutations affecting the bxd region show that (1) redundant or cooperatively acting sequences are required for Ubx gene expression in the anterior compartment of the first abdominal segment, and (2) the expression of Ubx in the posterior compartment of the third thoracic segment is modulated by positive and negative cis-regulatory elements.
Publisher version (URL)http://dx.doi.org/10.1007/BF00283837
Appears in Collections:(CBM) Artículos
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