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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/47835

Genetic and developmental analyses of chaetae pattern formation in Drosophila tergites

AutorMarí-Beffa, Manuel; Celis, José F. de ; García-Bellido, Antonio
Palabras clavePattern formation
Neurogenic genes
Achaete-scute gene complex
Cell interations
Fecha de publicación1991
CitaciónWilhelm Roux's Archives of Developmental Biology 200 (3): 132-142 (1991)
ResumenThe role of the achaete-scute complex and extramacrochaetae, Notch, Delta, Enhancer of split and Hairless genes in chaeta patterning in Drosophila tergites was studied in genetic mosaics and in mutant combinations. The mutant phenotypes of different alleles of each gene can be ordered in characteristic topographical seriations. These seriations are related to the pattern of proliferation of histoblasts and the time of singularization of sensory organ mother cells from surrounding epidermal cells. Genetic mosaics of lethal alleles show that these genes are fundamentally involved in this singularization and subsequent differentiation. The study of mutant combinations of alleles of these genes reveals specific relationships of epistasis and synergism between them. The results suggest that spatial and temporal variations in achaete-scute complex functional products in cells, modulated by the activity of other genes involved in signal transduction, define the patterned differentiation of sensory organs in tergites.
Versión del editorhttp://dx.doi.org/10.1007/BF00190232
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