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Título

Genetic interactions between the Polycomb locus and the Antennapedia and Bithorax complexes of Drosophila

AutorCapdevila, M. P.; Botas, J.; García-Bellido, Antonio
Palabras claveGene regulation
Developmental pathways
Antennapedia and Bithorax complexes in Drosophila
Fecha de publicación1986
EditorSpringer
CitaciónWilhelm Roux's Archives of Developmental Biology 195 (7): 417-432 (1986)
ResumenWe have studied the embryonic and adult phenotypes of genetic combinations between Polycomb (Pc), Regulator of bithorax (Rg-bx) and the genes of the Bithorax complex (BX-C) and the Antennapedia complex (ANT-C). The products of Pc and Rg-bx genes act antagonistically, their mutant combinations leading to the ectopic expression of genes of the BX-C and ANT-C. The genetic analysis of the Pc locus suggests it is a complex gene. Pc+ products behave as members of a ldquoregulatory setrdquo that negatively control the expression of BX-C and ANT-C genes. Genetic combinations between different doses of Pc, Rg-bx and the genes of the BX-C and ANT-C have phenotypes which may be interpreted as resulting from ectopic derepression of posterior selector genes repressing selector genes of anterior segments. The transformation phenotypes of certain genetic combinations differ in embryos and adults. A model of regulation of the BX-C and the ANT-C genes during the imaginal cell proliferation is presented, in which the specification state is maintained by self-activation of a given selector gene and down modulation of other selector genes in the same cell.
Versión del editorhttp://dx.doi.org/10.1007/BF00375746
URIhttp://hdl.handle.net/10261/47742
DOI10.1007/BF00375746
ISSN0340-0794
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