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Título

Metabolites in contact with the rat digestive tract after ingestion of a phenolic-rich dietary fiber matrix

AutorTouriño, Sonia; Pérez-Jiménez, Jara ; Mateos-Martín, María Luisa; Fuguet, Elisabet; Vinardell, M. Pilar; Cascante, Marta; Torres, Josep Lluís
Palabras claveGrape antioxidant dietary fiber
Polyphenols
Proanthocyanidins
Epicatechin
Metabolites
Bioavailability
Mass spectrometry
Feces
Cecal content
Colonic tissue
Fecha de publicación2011
EditorAmerican Chemical Society
CitaciónJournal of Agricultural and Food Chemistry 59(11): 5955-5963 (2011)
ResumenGrape antioxidant dietary fiber (GADF) is a phenolic-rich dietary fiber matrix. The aim of this work was to determine which phenolic compounds come into contact with colonic epithelial tissue after the ingestion of GADF. By use of HPLC-ESI-MS/MS techniques phenolic metabolites were detected in feces, cecal content, and colonic tissue from rats. Free (epi)catechin (EC) was detected in all three sources, and more than 20 conjugated metabolites of EC were also detected in feces. Fourteen microbially derived phenolic metabolites were also identified in feces, cecal content, and/or colonic tissue. These results show that during transit along the digestive tract, proanthocyanidin oligomers and polymers are depolymerized into EC units. After ingestion of GADF, free EC and its conjugates, as well as free and conjugated microbially derived phenolic metabolites, come into contact with the intestine epithelium for more than 24 h and may be partly responsible for the positive influence of GADF on gut health.
Versión del editorhttp://dx.doi.org/10.1021/jf200159f
URIhttp://hdl.handle.net/10261/47726
DOI10.1021/jf200159f
ISSN0021-8561
E-ISSN1520-5118
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