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Title

Synthesis of Fatty Acid Amides of Catechol Metabolites that Exhibit Antiobesity Properties

AuthorsAlmeida, Bruno; Joglar Tamargo, Jesús; Luque Rojas, María Jesús; Decara del Olmo, Juan Manuel; Bermúdez-Silva, Francisco Javier; Macías-González, Manuel; Fitó, Montserrat; Romero-Cuevas, Miguel; Farré, Magí; Covas, María Isabel; Rodríguez de Fonseca, Fernando; Torre, Rafael de la
KeywordsCB1
Endocannabinoids
Obesity
PPAR-α
Receptors
Issue Date2010
PublisherWiley-VCH
CitationChemMedChem
AbstractA series of fatty acid amides of 3,4-methylenedioxymethamphetamine (MDMA) catechol metabolites were synthesized in order to evaluate their biological activities. Upon administration, all synthesized compounds resulted in negative modulation of food intake in rats. The most active compounds have affinity for the CB1 receptor and/or PPAR-α; part of their biological activity may be caused by these double interactions.
Publisher version (URL)http://dx.doi.org/10.1002/cmdc.201000161
URIhttp://hdl.handle.net/10261/47442
DOI10.1002/cmdc.201000161
ISSN1860-7179
E-ISSN1860-7187
Appears in Collections:(IQAC) Artículos
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