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Título

Regulation of decapentaplegic expression during Drosophila wing veins pupal development

AutorSotillos, Sol ; Celis, José F. de
Palabras claveDrosophila
Decapentaplegic
Vein differentiation
Gene regulation
Wing
Fecha de publicación18-ene-2006
EditorElsevier
CitaciónMechanisms of Development Vol.123, Issue 3, March 2006, Pages 241-251
ResumenThe differentiation of veins in the Drosophila wing relies on localised expression of decapentaplegic (dpp) in pro-vein territories during pupal development. The expression of dpp in the pupal veins requires the integrity of the shortvein region (shv), localised 5′ to the coding region. It is likely that this DNA integrates positive and negative regulatory signals directing dpp transcription during pupal development. Here, we identify a minimal 0.9 kb fragment giving localised expression in the vein L5 and a 0.5 kb fragment giving expression in all longitudinal veins. Using a combination of in vivo expression of reporter genes regulated by shv sequences, in vitro binding assays and sequence comparisons between the shv region of different Drosophila species, we found binding sites for the vein-specific transciption factors Araucan, Knirps and Ventral veinless, as well as binding sites for the Dpp pathway effectors Mad and Med. We conclude that conserved vein-specific enhancers regulated by transcription factors expressed in individual veins collaborate with general vein and intervein regulators to establish and maintain the expression of dpp confined to the veins during pupal development
Versión del editorhttp://dx.doi.org/10.1016/j.mod.2005.12.002
URIhttp://hdl.handle.net/10261/4735
DOI10.1016/j.mod.2005.12.002
ISSN0925-4773 (Print)
1872-6356 (Online)
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