Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/4734
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

Independent roles of Drosophila Moesin in imaginal disc morphogenesis and hedgehog signalling

AuthorsMolnar, Cristina ORCID; Celis, José F. de CSIC ORCID
KeywordsMoesin
Hedgehog signalling
Epithelial morphogenesis
Pattern formation
Issue Date8-May-2006
PublisherElsevier
CitationMechanisms of Development Vol. 123, Issue 5, May 2006, Pages 337-351
AbstractThe three ERM proteins (Ezrin, Radixin and Moesin) form a conserved family required in many developmental processes involving regulation of the cytoskeleton. In general, the molecular function of ERM proteins is to link specific membrane proteins to the actin cytoskeleton. In Drosophila, loss of moesin (moe) activity causes incorrect localisation of maternal determinants during oogenesis, failures in rhabdomere differentiation in the eye and alterations of epithelial integrity in the wing imaginal disc. Some aspects of Drosophila Moe are related to the activity of the small GTPase RhoA, because the reduction of RhoA activity corrects many phenotypes of moe mutant embryos and imaginal discs. We have analysed the phenotype of moesin loss-of-function alleles in the wing disc and adult wing, and studied the effects of reduced Moesin activity on signalling mediated by the Notch, Decapentaplegic, Wingless and Hedgehog pathways. We found that reductions in Moesin levels in the wing disc cause the formation of wing-tissue vesicles and large thickenings of the vein L3, corresponding to breakdowns of epithelial continuity in the wing base and modifications of Hedgehog signalling in the wing blade, respectively. We did not observe any effect on signalling pathways other than Hedgehog, indicating that the moe defects in epithelial integrity have not generalised effects on cell signalling. The effects of moe mutants on Hedgehog signalling depend on the correct gene-dose of rhoA, suggesting that the requirements for Moesin in disc morphogenesis and Hh signalling in the wing disc are mediated by its regulation of RhoA activity. The mechanism linking Moesin activity with RhoA function and Hedgehog signalling remains to be elucidated
Publisher version (URL)http://dx.doi.org/10.1016/j.mod.2006.02.001
URIhttp://hdl.handle.net/10261/4734
DOI10.1016/j.mod.2006.02.001
ISSN0925-4773
E-ISSN1872-6356
Appears in Collections:(CBM) Artículos

Files in This Item:
File Description SizeFormat
Molnar and de Celis MoD.pdf2,43 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work

SCOPUSTM   
Citations

14
checked on May 14, 2022

WEB OF SCIENCETM
Citations

14
checked on May 20, 2022

Page view(s)

321
checked on May 22, 2022

Download(s)

234
checked on May 22, 2022

Google ScholarTM

Check

Altmetric

Dimensions


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.