English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/47195
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Animal models for neurodegenerative diseases

AutorPascual Bravo, Alberto ; Hidalgo Figueroa, María; Gómez-Díaz, Raquel; López-Barneo, José ; Piruat, José I.; Pintado, C. Oscar
Palabras claveAnimal care
Fermentation industry
Natural products
Polymers
Fecha de publicación7-dic-2007
CitaciónEP2067858-A1
ResumenThe invention provides a non-human animal model of Parkinson's disease based on animals which carry a modified version of the GDNF gene which comprises recombinase target sites flanking an essential part of said gene and a transgene which encodes for a recombinase specific for the target sites in the GDNF gene and which can be activated at will by administering a given compound to the animal. Activation of the recombinase in adult animals leads to a progressive catecholaminergic neuronal death. The invention also provides the use of said animals for the study of the pathogenesis of Parkinson's disease and for the identification of GDNF targets (which preserve the neurons from degeneration) as well as GDNF agonists and activators.
Descripción38 páginas, 8 figuras, 1 tabla. Fecha de prioridad: 07/12/2007. IPC: A01K-067/00; A61K-049/00; C07K-014/00; C12N-015/00. Solicitante: Universidad de Sevilla.
URIhttp://hdl.handle.net/10261/47195
Aparece en las colecciones: (IBIS) Patentes
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
EP2067858A1.pdf2,98 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.