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http://hdl.handle.net/10261/47082
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Fierro-González, Juan Carlos | - |
dc.contributor.author | González-Barrios, María | - |
dc.contributor.author | Miranda-Vizuete, Antonio | - |
dc.contributor.author | Swoboda, Peter | - |
dc.date.accessioned | 2012-03-15T09:02:41Z | - |
dc.date.available | 2012-03-15T09:02:41Z | - |
dc.date.issued | 2011-02-18 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications 406(3): 478-482 (2011) | es_ES |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | PMID 21334311 | - |
dc.identifier.uri | http://hdl.handle.net/10261/47082 | - |
dc.description | 25 páginas, 3 figuras. | es_ES |
dc.description.abstract | Dietary restriction (DR) is the only environmental intervention known to extend adult lifespan in a wide variety of animal models. However, the genetic and cellular events that mediate the anti-aging programs induced by DR remain elusive. Here, we used the nematode Caenorhabditis elegans to provide the first in vivo evidence that a thioredoxin (TRX-1) regulates adult lifespan extension induced by DR. We found that deletion of the gene trx-1 completely suppressed the lifespan extension caused by mutation of eat-2, a genetic surrogate of DR in the worm. However, trx-1 deletion only partially suppressed the long lifespan caused by mutation of the insulin-like receptor gene daf-2 or by mutation of the sensory cilia gene osm-5. A trx-1::GFP translational fusion expressed from its own promoter in ASJ neurons (Ptrx-1::trx-1::GFP) rescued the trx-1 deletion-mediated suppression of the lifespan extension caused by mutation of eat-2. This rescue was not observed when trx-1::GFP was expressed from the ges-1 promoter in the intestine. In addition, overexpression of Ptrx-1::trx-1::GFP extended lifespan in wild type, but not in eat-2 mutants. trx-1 deletion almost completely suppressed the lifespan extension induced by dietary deprivation (DD), a non-genetic, nutrient-based model of DR in the worm. Moreover, DD upregulated the expression of a trx-1 promoter-driven GFP reporter gene (Ptrx-1::GFP) in ASJ neurons of aging adults, but not that of control Pgpa-9::GFP (which is also expressed in ASJ neurons). We propose that DR activates TRX-1 in ASJ neurons during aging, which in turn triggers TRX-1-dependent mechanisms to extend adult lifespan in the worm. | es_ES |
dc.description.sponsorship | This study was supported by Grants from The Swedish Foundation for Strategic Research, The Swedish Research Council and The NordForsk Nordic C. elegans Network to P.S.; from Instituto de Salud Carlos III (Projects PI050065 and PI080557, co-financed by Fondo Social Europeo, FEDER) and Junta de Andalucía (Projects CVI-3629 and CVI-2697) to A.M.V. | - |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.isversionof | Postprint | - |
dc.rights | openAccess | es_ES |
dc.subject | Caenorhabditis elegans | es_ES |
dc.subject | Thioredoxin | es_ES |
dc.subject | Aging | es_ES |
dc.subject | Lifespan | es_ES |
dc.subject | Dietary restriction | es_ES |
dc.title | The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.bbrc.2011.02.079 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.bbrc.2011.02.079 | es_ES |
dc.identifier.e-issn | 1090-2104 | - |
dc.contributor.funder | Swedish Foundation for Strategic Research | - |
dc.contributor.funder | Swedish Research Council | - |
dc.contributor.funder | NordForsk | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | European Commission | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004785 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Fierro-Gonzalez_(PMID 21334311).pdf | 159,18 kB | Adobe PDF | Visualizar/Abrir |
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