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dc.contributor.authorGarcía, Juan A. L.-
dc.contributor.authorFernàndez-Guerra, Antoni-
dc.contributor.authorCasamayor, Emilio O.-
dc.date.accessioned2012-03-14T13:20:57Z-
dc.date.available2012-03-14T13:20:57Z-
dc.date.issued2011-
dc.identifier.citationMolecular Phylogenetics and Evolution 61(3) : 650-658 (2011)es_ES
dc.identifier.issn1055-7903-
dc.identifier.urihttp://hdl.handle.net/10261/47066-
dc.description9 páginas, 6 figuras, 4 tablas.es_ES
dc.description.abstractComparative genomics is an essential tool to unravel how genomes change over evolutionary time and to gain clues on the links between functional genomics and evolution. In prokaryotes, the large, good quality, genome sequences available in public databases and the recently developed large-scale computational methods, offer an unprecedent view on the ecology and evolution of microorganisms through comparative genomics. In this work, we examined the links among genome structure (i.e., the sequential distribution of nucleotides itself by detrended fluctuation analysis, DFA) and genomic diversity (i.e., gene functionality by Clusters of Orthologous Genes, COGs) in 828 full sequenced prokaryotic genomes from 548 different bacteria and archaea species. DFA scaling exponent a indicated persistent long-range correlations (fractality) in each genome analyzed. Higher resolution power was found when considering the sequential succession of purine (AG) vs. pyrimidine (CT) bases than either keto (GT) to amino (AC) forms or strongly (GC) vs. weakly (AT) bonded nucleotides. Interestingly, the phyla Aquificae, Fusobacteria, Dictyoglomi, Nitrospirae, and Thermotogae were closer to archaea than to their bacterial counterparts. A strong significant correlation was found between scaling exponent a and COGs distribution, and we consistently observed that the larger a the more heterogeneous was the gene distribution within each functional category, suggesting a close relationship between primary nucleotides sequence structure and functional genes compositiones_ES
dc.description.sponsorshipWe are thankful to Centre de Supercomputació de Catalunya (www.cesca.es) for supercomputing facilities and to Marine Genomics Europe (Network of Excellence Grant GOCE-CT-2003- 505403 from the EU-FP6 to EOC) for training courses in bioinformatics. This work was also financed by grant PIRENA CGL2009- 13318-C02-01 from the Spanish Ministry of Science (MICINN) to EOC, and FI predoctoral scholarship from the Catalonian Departament d’Universitats, Recerca i Societat de la Informació (DURSI) to JALG.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsclosedAccesses_ES
dc.subjectDNA walkes_ES
dc.subjectDetrended fluctuation analysis (DFA)es_ES
dc.subjectMicrobial ecologyes_ES
dc.subjectLong-range correlationes_ES
dc.subjectComparative genome analyseses_ES
dc.subjectLarge-scale genome structurees_ES
dc.titleA close relationship between primary nucleotides sequence structure and the composition of functional genes in the genome of prokaryoteses_ES
dc.typeArtículoes_ES
dc.identifier.doi10.1016/j.ympev.2011.08.011-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.ympev.2011.08.011es_ES
dc.identifier.e-issn1095-9513-
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