English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/47066
Título

A close relationship between primary nucleotides sequence structure and the composition of functional genes in the genome of prokaryotes

AutorGarcía, Juan A. L.; Fernàndez-Guerra, Antoni ; Casamayor, Emilio O.
Palabras claveDNA walk
Detrended fluctuation analysis (DFA)
Microbial ecology
Long-range correlation
Comparative genome analyses
Large-scale genome structure
Fecha de publicación2011
EditorElsevier
CitaciónMolecular Phylogenetics and Evolution 61(3) : 650-658 (2011)
ResumenComparative genomics is an essential tool to unravel how genomes change over evolutionary time and to gain clues on the links between functional genomics and evolution. In prokaryotes, the large, good quality, genome sequences available in public databases and the recently developed large-scale computational methods, offer an unprecedent view on the ecology and evolution of microorganisms through comparative genomics. In this work, we examined the links among genome structure (i.e., the sequential distribution of nucleotides itself by detrended fluctuation analysis, DFA) and genomic diversity (i.e., gene functionality by Clusters of Orthologous Genes, COGs) in 828 full sequenced prokaryotic genomes from 548 different bacteria and archaea species. DFA scaling exponent a indicated persistent long-range correlations (fractality) in each genome analyzed. Higher resolution power was found when considering the sequential succession of purine (AG) vs. pyrimidine (CT) bases than either keto (GT) to amino (AC) forms or strongly (GC) vs. weakly (AT) bonded nucleotides. Interestingly, the phyla Aquificae, Fusobacteria, Dictyoglomi, Nitrospirae, and Thermotogae were closer to archaea than to their bacterial counterparts. A strong significant correlation was found between scaling exponent a and COGs distribution, and we consistently observed that the larger a the more heterogeneous was the gene distribution within each functional category, suggesting a close relationship between primary nucleotides sequence structure and functional genes composition
Descripción9 páginas, 6 figuras, 4 tablas.
Versión del editorhttp://dx.doi.org/10.1016/j.ympev.2011.08.011
URIhttp://hdl.handle.net/10261/47066
DOI10.1016/j.ympev.2011.08.011
ISSN1055-7903
E-ISSN1095-9513
Aparece en las colecciones: (CEAB) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.