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Título

Synthesis and structural properties of oligonucleotides covalently linked to acridine and quindoline derivatives through a threoninol linker

AutorEritja Casadellà, Ramón; Mazzini, Stefania; Ferreira, Rubén; Aviñó, Anna
Palabras claveOligonucleotide synthesis
DNA duplex
DNA-binding drugs
DNA
Intercalating agents
Acridine
Quindoline
Threoninol
Quadruplex
Thrombin binding aptamer
NMR
Fecha de publicación1-nov-2010
EditorElsevier
CitaciónBioorganic and Medicinal Chemistry 18(21): 7348–7356 (2010)
ResumenOligonucleotide conjugates containing acridine and quindoline derivatives linked through a threoninol molecule were synthesized. We showed that these conjugates formed duplexes and quadruplexes with higher thermal stability than the corresponding unmodified oligonucleotides. When acridine is located in the middle of the sequence, DNA duplexes have a similar stability independently of the natural base present in front of acridine. Self-complementary oligonucleotides and thrombin binding aptamers (TBA) carrying the acridine and quindoline molecules are studied by NMR.
Versión del editorhttp://dx.doi.org/10.1016/j.bmc.2010.09.023
URIhttp://hdl.handle.net/10261/46951
DOI10.1016/j.bmc.2010.09.023
ISSN0968-0896
E-ISSN1464-3391
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