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Título

The Ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway

AutorNavas, Luis F. de ; Garaulet, Daniel L. ; Sánchez-Herrero, Ernesto
Palabras claveHox
Ultrabithorax
Decapentaplegic
Size control
Imaginal disc
Drosophila
Fecha de publicación18-oct-2006
EditorCompany of Biologists
CitaciónDevelopment 133, 4495-4506 (2006)
ResumenThe halteres and wings of Drosophila are homologous thoracic appendages, which share common positional information provided by signaling pathways. The activity in the haltere discs of the Ultrabithorax (Ubx) Hox gene establishes the differences between these structures, their different size being an obvious one. We show here that Ubx regulates the activity of the Decapentaplegic (Dpp) signaling pathway at different levels, and that this regulation is instrumental in establishing the size difference. Ubx downregulates dpp transcription and reduces Dpp diffusion by repressing the expression of master of thick veins and division abnormally delayed and by increasing the levels of thick veins, one of the Dpp receptors. Our results suggest that modulation in Dpp expression and spread accounts, in part, for the different size of halteres and wings.
DescripciónArticle available at http://dx.doi.org/10.1242/dev.02609
URIhttp://hdl.handle.net/10261/4685
ISSN0950-1991
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