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Título

Characterization of human thioredoxin-like-1: Potential involvement in the cellular response against glucose deprivation

AutorJiménez, Alberto ; Pelto-Huikko, Markku; Gustafsson, Jan-Åke; Miranda-Vizuete, Antonio
Palabras claveThioredoxin
Glucose deprivation
Cell death
Stress
Fecha de publicación19-ene-2006
EditorElsevier
Federation of European Biochemical Societies
CitaciónFEBS Letters 580(3): 960-967 (2006)
ResumenThe thioredoxin system, composed of thioredoxin (Trx) and thioredoxin reductase (TrxR), emerges as one of the most important thiol-based systems involved in the maintenance of the cellular redox balance. Thioredoxin-like-1 (TXL-1) is a highly conserved protein comprising an N-terminal Trx domain and a C-terminal domain of unknown function. Here we show that TXL-1 is a substrate for the cytosolic selenoprotein TrxR-1. In situ hybridization experiments demonstrates high expression of Txl-1 mRNA in various areas of central nervous system and also in some reproductive organs. Glucose deprivation, but not hydrogen peroxide treatment, reduced the levels of endogenous TXL-1 protein in HEK-293 cell line. Conversely, overexpression of TXL-1 protects against glucose deprivation-induced cytotoxicity. Taken together, the finding that Txl-1 mRNA is highly expressed in tissues which use glucose as a primary energy source and the modulation of TXL-1 levels upon glucose deprivation indicate that TXL-1 might be involved in the cellular response to sugar starvation stress.
Descripción27 páginas, 6 figuras. Datos suplementarios.
Versión del editorhttp://dx.doi.org/10.1016/j.febslet.2006.01.025
URIhttp://hdl.handle.net/10261/46508
DOI10.1016/j.febslet.2006.01.025
ISSN0014-5793
E-ISSN1873-3468
ReferenciasPMID: 16438969
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