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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Pascual Bravo, Alberto | - |
dc.contributor.author | Huang, Kai-Lian | - |
dc.contributor.author | Preat, Thomas | - |
dc.date.accessioned | 2012-03-01T10:00:32Z | - |
dc.date.available | 2012-03-01T10:00:32Z | - |
dc.date.issued | 2005-01-13 | - |
dc.identifier.citation | Nucleic Acids Research 33(1): e7 (2005) | es_ES |
dc.identifier.issn | 1362-4962 | - |
dc.identifier.other | PMID: 15653628 | - |
dc.identifier.other | PMC546177 | - |
dc.identifier.uri | http://hdl.handle.net/10261/46431 | - |
dc.description | 4 páginas, 3 figuras. | es_ES |
dc.description.abstract | The Gal4–UAS enhancer trap system is useful for driving gene expression in various tissues. A new tool that extends Gal4 technology is described here. A fusion protein containing the Gal4 binding domain and the repression domain of the isolator suppressor of hairy wing was placed under the control of a heat shock-inducible promoter. The construct mediates the conditional repression of genes located downstream of a UAS sequence. The repressive effects of the chimeric protein on fasII gene expression were tested by western-blot analysis and in brain sections of adult Drosophila. Owing to the increasing number of Gal4 and UAS transgenic lines, this versatile system will facilitate the study of gene function. | es_ES |
dc.description.sponsorship | We thank the Human Frontier Science Program, the Association pour la Recherche contre le Cancer (ARC) and the Fondation pour la Recherche sur le Cerveau (FRC) for financial support. A.P. was supported by the Fondation pour la Recherche Médicale and the European Molecular Biology Organization. Funding to pay the Open Access publication charges for this article was provided by the ARC. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | DNA-binding proteins | es_ES |
dc.subject | Drosophila | es_ES |
dc.subject | Nuclear proteins | es_ES |
dc.subject | Repressor proteins | es_ES |
dc.subject | Saccharomyces cerevisiae proteins | es_ES |
dc.subject | Transcription factors | es_ES |
dc.title | Conditional UAS-targeted repression in Drosophila | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1093/nar/gni006 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1093/nar/gni006 | es_ES |
dc.identifier.e-issn | 0305-1048 | - |
dc.identifier.pmid | 15653628 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
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Pascual_2005.pdf | 1,89 MB | Adobe PDF | Visualizar/Abrir |
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