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Antitumor activity of new hydridotris(pyrazolyl)borate ruthenium(II) complexes containing the phosphanes PTA and 1-CH3–PTA

AuthorsGarcía-Fernández, Almudena; García-Navas, Rósula; Sierra, Beatriz G.; Mollinedo, Faustino
Issue Date30-Sep-2010
PublisherRoyal Society of Chemistry (Great Britain)
CitationDalton Transactions 39(42): 10186-10196( 2010)
AbstractThe synthesis and full characterization of new half-sandwich ruthenium(II) complexes containing κ3(N,N,N)-hydridotris(pyrazolyl)borate (κ3(N,N,N)-Tp) and the water-soluble phosphanes 1,3,5-triaza-7-phosphatricyclo[,7]decane (PTA) and 1-methyl-3,5-diaza-1-azonia-7-phosphatricyclo[,7]decane (1-CH3-PTA) has been explored. Single crystal X-ray diffraction analysis for complex [RuCl{κ3(N,N,N)-Tp}(PMe2Ph)(1-CH3-PTA)][CF3SO3]·2NCMe is also reported. DNA binding properties of the ruthenium complexes have been evaluated by mobility shift assay and MALDI-TOF mass spectrometry. The in vitro antitumor activity of these compounds was assessed by examining their ability to inhibit cell proliferation in a number of human cancer cell lines (NCI-H460, SF-268, MCF-7) and non-tumor human umbilical vein endothelial cells (HUVEC). Some of these new compounds show promising cytotoxic activity with IC50 values in the low micromolar range, and display differential effects on cancer and normal cell growth.
Description11 páginas, 4 figuras, 5 tablas.-- et al.
Publisher version (URL)http://dx.doi.org/10.1039/C0DT00206B
Appears in Collections:(IBMCC) Artículos
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