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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/45715
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dc.contributor.advisorOrfao, Alberto-
dc.contributor.authorSchmidt-Hieber, M.-
dc.contributor.authorPérez-Andrés, Martin-
dc.contributor.authorPaiva, Bruno-
dc.contributor.authorFlores-Montero, Juan-
dc.contributor.authorGutiérrez, Norma Carmen-
dc.contributor.authorMatarraz, Sergio-
dc.contributor.authorSan Miguel, Jesús F.-
dc.date.accessioned2012-02-16T10:30:10Z-
dc.date.available2012-02-16T10:30:10Z-
dc.date.issued2011-02-01-
dc.identifier.citationHaematologica 96(2): 328-332 (2011)es_ES
dc.identifier.issn0390-6078-
dc.identifier.urihttp://hdl.handle.net/10261/45715-
dc.description5 páginas, 1 figura, 2 tablas.-- et al.-
dc.description.abstractAberrant CD117 expression is associated with a favorable outcome in multiple myeloma. We analyzed 106 patients with symptomatic multiple myeloma (n=50), smoldering multiple myeloma (n=38) and monoclonal gammopathy of undetermined significance (n=18) to elucidate biological features of CD117+ versus CD117− monoclonal gammopathies. CD117+ (mono)clonal plasma cells were detected in 30% symptomatic multiple myeloma, 45% smoldering multiple myeloma and 72% monoclonal gammopathy of undetermined significance patients. CD117 expression was associated with higher percentages of normal bone marrow plasma cells, CD117+ myeloid precursors and CD38+ B lymphocytes in all monoclonal gammopathies. Conversely, the number of bone marrow CD34+ myeloid cells and peripheral blood neutrophils was reduced among CD117+ multiple myeloma but not monoclonal gammopathy of undetermined significance patients. CD117 expression by (mono)clonal plasma cells is associated with uniquely altered patterns of production of hematopoietic bone marrow cells with decreased peripheral blood neutrophil counts and persistence of normal residual bone marrow plasma cells.es_ES
dc.description.sponsorshipthis work was supported by the Cooperative Research Thematic Network (RTICs; RTICC RD06/0020/0035, RD06/0020/0006 and G03/136), MM Jevitt, SL firm, Instituto de Salud Carlos III/Subdirección General de Investigación Sanitaria (FIS: PI060339; 02/0905; 01/0089/01-02; PS09/01897) and Gerencia Regional de Salud de Castilla y León; Ayuda de Excelencia de Castilla y León, Consejeria de Educación (EDU/894/2009, GR37), and Consejería de Sanidad (557/A/10), Junta de Castilla y León, Valladolid, Spain. This work was further supported by a grant from the Dr. Werner Jackstädt-Foundation (Wuppertal, Germany).-
dc.language.isoenges_ES
dc.publisherFerrata Storti Foundationes_ES
dc.rightsopenAccesses_ES
dc.subjectMultiparameter Flow Cytometryes_ES
dc.subjectMyeloid Maturationes_ES
dc.subjectCD117 Expressiones_ES
dc.subjectMonoclonal Gammopathyes_ES
dc.subjectLymphoid Maturationes_ES
dc.subjectNormal Residual Plasma Cellses_ES
dc.titleCD117 expression in gammopathies is associated with an altered maturation of the myeloid and lymphoid hematopoietic celles_ES
dc.typeartículoes_ES
dc.identifier.doi10.3324/haematol.2010.031872-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.3324/haematol.2010.031872es_ES
dc.identifier.pmid20971816-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
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