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CD117 expression in gammopathies is associated with an altered maturation of the myeloid and lymphoid hematopoietic cell

AuthorsSchmidt-Hieber, M.; Pérez-Andrés, Martin; Paiva, Bruno; Flores-Montero, Juan; Gutiérrez, Norma Carmen; Matarraz, Sergio; San Miguel, Jesús F.
AdvisorOrfao, Alberto
KeywordsMultiparameter Flow Cytometry
Myeloid Maturation
CD117 Expression
Monoclonal Gammopathy
Lymphoid Maturation
Normal Residual Plasma Cells
Issue Date1-Feb-2011
PublisherFerrata Storti Foundation
CitationHaematologica 96(2): 328-332 (2011)
AbstractAberrant CD117 expression is associated with a favorable outcome in multiple myeloma. We analyzed 106 patients with symptomatic multiple myeloma (n=50), smoldering multiple myeloma (n=38) and monoclonal gammopathy of undetermined significance (n=18) to elucidate biological features of CD117+ versus CD117− monoclonal gammopathies. CD117+ (mono)clonal plasma cells were detected in 30% symptomatic multiple myeloma, 45% smoldering multiple myeloma and 72% monoclonal gammopathy of undetermined significance patients. CD117 expression was associated with higher percentages of normal bone marrow plasma cells, CD117+ myeloid precursors and CD38+ B lymphocytes in all monoclonal gammopathies. Conversely, the number of bone marrow CD34+ myeloid cells and peripheral blood neutrophils was reduced among CD117+ multiple myeloma but not monoclonal gammopathy of undetermined significance patients. CD117 expression by (mono)clonal plasma cells is associated with uniquely altered patterns of production of hematopoietic bone marrow cells with decreased peripheral blood neutrophil counts and persistence of normal residual bone marrow plasma cells.
Description5 páginas, 1 figura, 2 tablas.-- et al.
Publisher version (URL)http://dx.doi.org/10.3324/haematol.2010.031872
Appears in Collections:(IBMCC) Artículos
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