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Multifunctional nanomechanical systems for multiplexed highly selective and sensitive biological detection

AutorTamayo de Miguel, Francisco Javier ; Kosaka, Priscila M. ; Mertens, Johann ; Calleja, Montserrat
Fecha de publicación2010
CitaciónNanoSpain 2010
ResumenPrediction of risk factors and early diagnosis of disease are the best means to preserve health and to avoid costly and inefficient medical interventions after symptoms and disease have developed. Current platforms for analysis require large amount of sample, have many sample pre-treatment steps prone to human error, are relatively slow, suffer of low sensitivity for the detection of multiple malignancies, and often provide false positives and negatives. In addition, these instruments are bulky equipment that is frequently not available to clinics or point of care diagnosis. The goal of discovering new devices and new transduction concepts for biological detection remains of paramount importance. Nanotechnology based approaches are promising candidates for providing portable and low cost nanosensor devices, capable of analyzing tiny amounts of sample, and specifically disease markers from patients. Also, the advancement of new approaches that provide the needed robustness and reproducibility of the response, as well as a high degree of multiplexing, is needed. MEMS/NEMS devices are good candidates to attain this goal, but this approach needs the further development of advanced instrumentation which demands combined expertise in fabrication, design, engineering and modelling. We have found that a private – public partnership is especially suitable to attain the cited purposes. In this work, two spin-off companies Mecwins S.L. and Nanosens Gmbh have collaborated with our group to develop an instrument with the capability for highly multiplexed detection (up to 128 sensors in parallel already demonstrated) together with an accurate control of the gas environment[1] and a biochip comprising 128 cantilevers in groups of 8 cantilevers for differential measurements.
DescripciónTrabajo presentado a NanoSpain 2010 celebrado en Málaga del 23-26 Marzo, 2010. -- Javier Tamayo et al...
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