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Perspectives on fish gonadotropins and their receptors

AutorLevavi-Sivan, Berta; Bogerd, Jan; Mañanós, Evaristo L. ; Gómez Peris, Ana María; Lareyre, Jean Jacques
Palabras claveEstradiol
11-Ketotestosterone
Follicle-stimulating hormone
Luteinizing hormone
Pituitary
Recombinant
FSH receptor
LH receptor
Fecha de publicaciónfeb-2010
EditorElsevier
Academic Press
CitaciónGeneral and Comparative Endocrinology 165(3):412-437 (2010)
ResumenTeleosts lack a hypophyseal portal system and hence neurohormones are carried by nerve fibers from the preoptic region to the pituitary. The various cell types in the teleost pituitary are organized in discrete domains. Fish possess two gonadotropins (GtH) similar to FSH and LH in other vertebrates; they are heterodimeric hormones that consist of a common α subunit non-covalently associated with a hormone-specific β subunit. In recent years the availability of molecular cloning techniques allowed the isolation of the genes coding for the GtH subunits in 56 fish species representing at least 14 teleost orders. Advanced molecular engineering provides the technology to produce recombinant GtHs from isolated cDNAs. Various expression systems have been used for the production of recombinant proteins. Recombinant fish GtHs were produced for carp, seabream, channel and African catfish, goldfish, eel, tilapia, zebrafish, Manchurian trout and Orange-spotted grouper. The hypothalamus in fishes exerts its regulation on the release of the GtHs via several neurohormones such as GnRH, dopamine, GABA, PACAP, IGF-I, norepinephrine, NPY, kisspeptin, leptin and ghrelin. In addition, gonadal steroids and peptides exert their effects on the gonadotropins either directly or via the hypothalamus. All these are discussed in detail in this review. In mammals, the biological activities of FSH and LH are directed to different gonadal target cells through the cell-specific expression of the FSH receptor (FSHR) and LH receptor (LHR), respectively, and the interaction between each gonadotropin-receptor couple is highly selective. In contrast, the bioactivity of fish gonadotropins seems to be less specific as a result of promiscuous hormone-receptor interactions, while FSHR expression in Leydig cells explains the strong steroidogenic activity of FSH in certain fish species.
Descripción84 p., il., y bibliografía
Versión del editorhttp://dx.doi.org/10.1016/j.ygcen.2009.07.019
URIhttp://hdl.handle.net/10261/44879
DOI10.1016/j.ygcen.2009.07.019
ISSN1095-6840
E-ISSN1095-6840
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