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Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes

AuthorsAlvarez, Yolanda ; Valera, Isela; Municio, Cristina ; Hugo, Etzel; Rodríguez, Mario ; Fernández, Nieves ; Sánchez Crespo, Mariano
Issue Date2010
PublisherHindawi Publishing Corporation
CitationMediators of Inflammation (2010)
AbstractThe variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism. Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-derived dendritic cells since it induced the production of PGE2, PGD2, and several cytokines including a robust IL-10 response. Zymosan activated κB-binding activity, but inhibition of NF-κB was associated with enhanced IL-10 production. In contrast, treatments acting on CREB (CRE binding protein), including PGE2, showed a direct correlation between CREB activation and IL-10 production. Therefore, in dendritic cells zymosan induces il10 transcription by a CRE-dependent mechanism that involves autocrine secretion of PGE2, thus unraveling a functional cooperation between eicosanoid production and cytokine production.
Description14 páginas, 6 figuras.-- This is an open access article distributed under the Creative Commons Attribution License.-- et al.
Publisher version (URL)http://dx.doi.org/10.1155/2010/201929
Appears in Collections:(IBGM) Artículos
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