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Synthesis and analgesic activity of a series of new azaalkane bis-guanidinium and bis(2-aminoimidazolinium) compounds

AuthorsDardonville, Christophe ; Rozas, Isabel; Goya, Pilar ; Girón, Rocío; Goicoechea, Carlos; Martín, M. Isabel
Issue Date3-Feb-2003
PublisherPergamon Press
CitationBioorganic & Medicinal Chemistry 11: 1283–1291 (2003)
AbstractIn the present paper, we wish to report the synthesis and antinociceptive activity of a series of new azaalkane bis(2- aminoimidazolinium) compounds from which, N,N0-di(4,5-dihydro-1H-imidazol-2-yl)-3-aza-1,6-hexanediamine 2a has shown the best analgesic properties in vivo in two different assays (i.e., acetic acid-induced writhing test and hot-plate test in mice), as well as oral bioavailability
Publisher version (URL)http://dx.doi.org/10.1016/S0968-0896(02)00637-5
Appears in Collections:(IQM) Artículos
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