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http://hdl.handle.net/10261/44402
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Jagerovic, Nadine | - |
dc.contributor.author | Hernández-Folgado, Laura | - |
dc.contributor.author | Alkorta, Ibon | - |
dc.contributor.author | Goya, Pilar | - |
dc.contributor.author | Serrano, Antonia | - |
dc.contributor.author | Rodríguez de Fonseca, Fernando | - |
dc.contributor.author | Dannert, M. Teresa | - |
dc.contributor.author | Alsasua, Ángela | - |
dc.contributor.author | Suardiaz, Margarita | - |
dc.contributor.author | Pascual, David | - |
dc.contributor.author | Martín, M. Isabel | - |
dc.date.accessioned | 2012-01-18T09:48:11Z | - |
dc.date.available | 2012-01-18T09:48:11Z | - |
dc.date.issued | 2004-05-20 | - |
dc.identifier.citation | Journal of Medicinal Chemistry 47 (11) : 2939–2942 (2004) | es_ES |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.uri | http://hdl.handle.net/10261/44402 | - |
dc.description.abstract | A new series of 1,2,4-triazoles have been prepared and the evaluation of their cannabinoid properties have been carried out. Compound 8 showed cannabinoid silent antagonist activity in mouse vas deferens and guinea pig ileum preparations and in vivo assays (cannabinoid tetrad) in mouse. It did not have intrinsic activity in these bioassays, and therefore, it did not behave as a partial agonist or an inverse agonist | es_ES |
dc.description.sponsorship | This work was supported by Spanish Grant SAF 00-0114-C02. L.H.-F. is recipient of the I3P Fellowship from the C.S.I.C. Laboratorios Dr. Esteve, S.A. is gratefully acknowledged. L.H.-F. thanks the Spanish Society of Therapeutic Chemistry (SEQT) for the Ramon Madroñero Young Researcher Award. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Cannabinoid antagonist | es_ES |
dc.title | Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1021/jm031099y | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1021/jm031099y | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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