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Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif

AuthorsJagerovic, Nadine ; Hernández-Folgado, Laura ; Alkorta, Ibon ; Goya, Pilar ; Serrano, Antonia; Rodriguez de Fonseca, Fernando; Dannert, M. Teresa; Alsasua, Ángela; Suardiaz, Margarita; Pascual, David; Martín, M. Isabel
KeywordsCannabinoid Antagonist
Issue Date20-May-2004
PublisherAmerican Chemical Society
CitationJournal of Medicinal Chemistry 47 (11) : 2939–2942 (2004)
AbstractA new series of 1,2,4-triazoles have been prepared and the evaluation of their cannabinoid properties have been carried out. Compound 8 showed cannabinoid silent antagonist activity in mouse vas deferens and guinea pig ileum preparations and in vivo assays (cannabinoid tetrad) in mouse. It did not have intrinsic activity in these bioassays, and therefore, it did not behave as a partial agonist or an inverse agonist
Publisher version (URL)http://dx.doi.org/10.1021/jm031099y
Appears in Collections:(IQM) Artículos
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