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Fulminant cryptosporidiosis associated with digestive adenocarcinoma in SCID mice infected with Cryptosporidium parvum TUM1 strain

AuthorsCertad, Gabriela; Sitjà-Bobadilla, Ariadna ; Álvarez-Pellitero, Mª del Pilar
KeywordsCryptosporidium parvum TUM1
Fulminant infection
Intestinal adenocarcinoma
Intraepithelial neoplasia
SCID mice
Issue DateNov-2010
CitationInternational Journal for Parasitology 40(13): 1469-1475 (2010)
AbstractWe demonstrated recently that Cryptosporidium parvum IOWA strain induces in situ ileo-caecal adenocarcinoma in an animal model. Herein, the ability of another C. parvum strain and other Cryptosporidium species to induce digestive neoplasia in dexamethasone-treated SCID mice was explored. SCID mice infected with C. parvum TUM1 developed a fulminant cryptosporidiosis associated with intramucosal adenocarcinoma, which is considered an early histological sign of invasive cancer. Both, evidence of a role of C. parvum in adenocarcinoma induction and the extended prevalence of cryptosporidiosis worldwide, suggest that the risk of C. parvum induced gastro-intestinal cancer in humans should be assessed.
Description22 p., figuras, tablas y bibliografía. Ariadna Sitjà-Bobadilla [et al.]
Publisher version (URL)http://dx.doi.org/10.1016/j.ijpara.2010.07.007
Appears in Collections:(IATS) Artículos
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