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Title

Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide

AuthorsCano, Carolina; Páez, Juan Antonio; Goya, Pilar CSIC ORCID; Serrano, Antonia; Pavón, Javier; Rodríguez de Fonseca, Fernando; Suardíaz, Margarita; Martín, María Isabel
KeywordsSulfamide
Anandamide
Arachidonyl
Cannabinoid
FAAH
Issue DateDec-2009
PublisherElsevier
CitationEuropean Journal of Medicinal Chemistry 44 : 4889–4895 (2009)
AbstractArachidonyl and linoleyl sulfamide derivatives have been synthesized and their potential cannabimi- metic properties evaluated in in vitro functional and binding assays. Replacement of the ethanolamide moiety of anandamide by –CH2NHSO2NH–R considerably reduces the CB1 receptor activity and only some of the compounds showed modest cannabinoid properties in binding assays. The new compounds were also tested as inhibitors of the FAAH enzyme but were inactive.
Publisher version (URL)http://dx.doi.org/10.1016/j.ejmech.2009.08.003
URIhttp://hdl.handle.net/10261/43914
DOIhttp://dx.doi.org/10.1016/j.ejmech.2009.08.003
ISSN0223-5234
Appears in Collections:(IQM) Artículos
(IQFR) Artículos
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