English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/43738
Título

Nuclear receptor BgFTZ-F1 regulates molting and the timing of ecdysteroid production during nymphal development in the hemimetabolous insect Blattella germanica

AutorCruz, Josefa ; Nieva, Claudia ; Mané-Padrós, Daniel; Martín Casacuberta, David A. ; Bellés, Xavier
Palabras claveFTZ-F1
Nuclear hormone receptor
Blattella germanica
20-Hydroxyecdysone
RNAi
Fecha de publicaciónnov-2008
EditorWiley-Blackwell
CitaciónDevelopmental Dynamics 237(11): 3179-3191 (2008)
ResumenPostembryonic development of holometabolous and hemimetabolous insects occurs through successive molts triggered by 20-hydroxyecdysone (20E). The molecular action of 20E has been extensively studied in holometabolous insects, but data on hemimetabolous are scarce. We have demonstrated that during the nymphal development of the hemimetabolous insect Blattella germanica, 20E binds to the heterodimeric receptor formed by the nuclear receptors BgEcR-A and BgRXR activating a cascade of gene expression, including the nuclear receptors BgE75 and BgHR3. Herein, we report the characterization of BgFTZ-F1, another nuclear hormone receptor involved in 20E action. BgFTZ-F1 is activated at the end of each instar, and RNAi has demonstrated that BgHR3 is needed for BgFTZ-F1 activation, and that BgFTZ-F1 has critical functions of during the last nymphal instar. Nymphs with silenced BgFTZ-F1 cannot ecdyse, arrest development, and show structures of ectodermal origin duplicated. BgFTZ-F1 also controls the timing of the ecdysteroid molting pulse.
Descripción13 páginas, 10 figuras, 2 tablas.
Versión del editorhttp://dx.doi.org/10.1002/dvdy.21728
URIhttp://hdl.handle.net/10261/43738
DOI10.1002/dvdy.21728
ISSN1058-8388
E-ISSN1097-0177
Aparece en las colecciones: (IBE) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.