English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/43735
Título

Bitter taste perception in Neanderthals through the analysis of the TAS2R38 gene

AutorLalueza-Fox, Carles ; Gigli, Elena ; Rasilla, Marco de la; Fortea, Javier; Rosas, Antonio
Palabras claveBitter taste
PTC
TAS2R38
Neanderthals
Fecha de publicacióndic-2009
EditorRoyal Society (Great Britain)
CitaciónBiology Letters 5(6): 809-811 (2009)
ResumenThe bitter taste perception (associated with the ability or inability to taste phenylthiocarbamide) is mediated by the TAS2R38 gene. Most of the variation in this gene is explained by three common amino-acid polymorphisms at positions 49 (encoding proline or alanine), 262 (alanine or valine) and 296 (valine or isoleucine) that determine two common isoforms: proline–alanine–valine (PAV) and alanine–valine–isoleucine (AVI). PAV is the major taster haplotype (heterozygote and homozygote) and AVI is the major non-taster haplotype (homozygote). Amino acid 49 has the major effect on the distinction between tasters and non-tasters of all three variants. The sense of bitter taste protects us from ingesting toxic substances, present in some vegetables, that can affect the thyroid when ingested in large quantities. Balancing selection has been used to explain the current high non-taster frequency, by maintaining divergent TAS2R38 alleles in humans. We have amplified and sequenced the TAS2R38 amino acid 49 in the virtually uncontaminated Neanderthal sample of El Sidrón 1253 and have determined that it was heterozygous. Thus, this Neanderthal was a taster individual, although probably slightly less than a PAV homozygote. This indicates that variation in bitter taste perception pre-dates the divergence of the lineages leading to Neanderthals and modern humans.
Descripción3 páginas, 1 figura.
Versión del editorhttp://dx.doi.org/10.1098/rsbl.2009.0532
URIhttp://hdl.handle.net/10261/43735
DOI10.1098/rsbl.2009.0532
E-ISSN1744-957X
Aparece en las colecciones: (MNCN) Artículos
(IBE) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.