Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/43729
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

A variant in the gene FUT9 is associated with susceptibility to placental malaria infection

AuthorsSikora, Martin; Ferrer Admetlla, Anna; Laayouni, Hafid CSIC ORCID; Bertranpetit, Jaume CSIC ORCID ; Casals, Ferran CSIC ORCID
Issue Date2009
PublisherOxford University Press
CitationHuman Molecular Genetics 18(16): 3163-3144 (2009)
AbstractMalaria in pregnancy forms a substantial part of the worldwide burden of malaria, with an estimated annual death toll of up to 200 000 infants, as well as increased maternal morbidity and mortality. Studies of genetic susceptibility to malaria have so far focused on infant malaria, with only a few studies investigating the genetic basis of placental malaria, focusing only on a limited number of candidate genes. The aim of this study therefore was to identify novel host genetic factors involved in placental malaria infection. To this end we carried out a nested case–control study on 180 Mozambican pregnant women with placental malaria infection, and 180 controls within an intervention trial of malaria prevention. We genotyped 880 SNPs in a set of 64 functionally related genes involved in glycosylation and innate immunity. A single nucleotide polymorphism (SNP) located in the gene FUT9, rs3811070, was significantly associated with placental malaria infection (odds ratio = 2.31, permutation P-value=0.028). Haplotypic analysis revealed a similarly strong association of a common haplotype of four SNPs including rs3811070. FUT9 codes for a fucosyl-transferase that is catalyzing the last step in the biosynthesis of the Lewis-x antigen, which forms part of the Lewis blood group-related antigens. These results therefore suggest an involvement of this antigen in the pathogenesis of placental malaria infection.
Description9 páginas, 3 figuras, 3 tablas.-- et al.
Publisher version (URL)http://dx.doi.org/10.1093/hmg/ddp240
URIhttp://hdl.handle.net/10261/43729
DOI10.1093/hmg/ddp240
ISSN0964-6906
E-ISSN1460-2083
Appears in Collections:(IBE) Artículos

Show full item record
Review this work

SCOPUSTM   
Citations

9
checked on May 20, 2022

WEB OF SCIENCETM
Citations

8
checked on May 18, 2022

Page view(s)

332
checked on May 21, 2022

Google ScholarTM

Check

Altmetric

Dimensions


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.