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Differences in capillary electrophoresis profiles of urinary and recombinant erythropoietin

AuthorsFrutos, Mercedes de; Diez-Masa, Jose Carlos; Cifuentes, Alejandro
KeywordsCapillary zone electrophoresis
Issue Date2003
CitationElectrophoresis 24 : 678–680 (2003)
AbstractDifferent profiles were obtained by capillary zone electrophoresis (CZE) of human ery- thropoietin (EPO) of recombinant and urinary origin. To unambiguously detect doping by EPO, direct methods able to determine the presence of the drug itself in a physio- logical fluid are required. Since the host cell line used for EPO production influences its glycosylation, the carbohydrate distribution of natural human EPO may be different from that of recombinant EPO. The different content in sialic acid groups between recombinant and endogenous EPO provide a basis for their distinction by CZE.
Publisher version (URL)http://dx.doi.org/10.1002/elps.200390080
Appears in Collections:(IQOG) Artículos
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