Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/43384COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.author | Sayagués, José María | - |
| dc.contributor.author | Fontanillo, Celia | - |
| dc.contributor.author | González González, María | - |
| dc.contributor.author | Sarasquete, María Eugenia | - |
| dc.contributor.author | Chillón, M. del Carmen | - |
| dc.contributor.author | García García, Eva María | - |
| dc.contributor.author | De Las Rivas, Javier | - |
| dc.contributor.author | Orfao, Alberto | - |
| dc.date.accessioned | 2011-12-15T13:14:40Z | - |
| dc.date.available | 2011-12-15T13:14:40Z | - |
| dc.date.issued | 2011 | - |
| dc.identifier.citation | PLoS ONE 5(10): e13752 (2010) | es_ES |
| dc.identifier.issn | 1932-6203 | - |
| dc.identifier.uri | http://hdl.handle.net/10261/43384 | - |
| dc.description | This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al. | - |
| dc.description.abstract | [Background]: For years, the genetics of metastatic colorectal cancer (CRC) have been studied using a variety of techniques. However, most of the approaches employed so far have a relatively limited resolution which hampers detailed characterization of the common recurrent chromosomal breakpoints as well as the identification of small regions carrying genetic changes and the genes involved in them. [Methodology/Principal Findings]: Here we applied 500K SNP arrays to map the most common chromosomal lesions present at diagnosis in a series of 23 primary tumours from sporadic CRC patients who had developed liver metastasis. Overall our results confirm that the genetic profile of metastatic CRC is defined by imbalanced gains of chromosomes 7, 8q, 11q, 13q, 20q and X together with losses of the 1p, 8p, 17p and 18q chromosome regions. In addition, SNP-array studies allowed the identification of small (<1.3 Mb) and extensive/large (>1.5 Mb) altered DNA sequences, many of which contain cancer genes known to be involved in CRC and the metastatic process. Detailed characterization of the breakpoint regions for the altered chromosomes showed four recurrent breakpoints at chromosomes 1p12, 8p12, 17p11.2 and 20p12.1; interestingly, the most frequently observed recurrent chromosomal breakpoint was localized at 17p11.2 and systematically targeted the FAM27L gene, whose role in CRC deserves further investigations. [Conclusions/Significance]: In summary, in the present study we provide a detailed map of the genetic abnormalities of primary tumours from metastatic CRC patients, which confirm and extend on previous observations as regards the identification of genes potentially involved in development of CRC and the metastatic process. | es_ES |
| dc.description.sponsorship | This work has been partially supported by grants from the Consejeria de Sanidad, Junta de Castilla y Leon, Valladolid, Spain (SAN191/SA09/06 and SAN673/SA39/08), Fundacion Memoria de Don Samuel Solorzano Barruso, Salamanca, Spain, Caja de Burgos (Obra Social), Burgos, Spain, Grupo Excelencia de Castilla y Leon (GR37) and the RTICC from the Instituto de Salud Carlos III (ISCIII), Ministerio de Ciencia e Innovacion, Madrid, Spain (RD06/0020/0035-FEDER). JM Sayagués, M Gonzalez, ME Sarasquete and MC Chillon are supported by grants (CP05/00321, FI08/00721, CA08/00212 and CA/07/00077, respectively) from the ISCIII, Ministerio de Ciencia e Innovación, Madrid, Spain. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | Public Library of Science | es_ES |
| dc.relation.isversionof | Publisher's version | - |
| dc.rights | openAccess | es_ES |
| dc.title | Mapping of Genetic Abnormalities of Primary Tumours from Metastatic CRC by High-Resolution SNP Arrays | es_ES |
| dc.type | artículo | es_ES |
| dc.identifier.doi | 10.1371/journal.pone.0013752 | - |
| dc.description.peerreviewed | Peer reviewed | es_ES |
| dc.relation.publisherversion | http://dx.doi.org/10.1371/journal.pone.0013752 | es_ES |
| dc.identifier.pmid | 21060790 | - |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
| item.languageiso639-1 | en | - |
| item.fulltext | With Fulltext | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
| item.cerifentitytype | Publications | - |
| item.grantfulltext | open | - |
| item.openairetype | artículo | - |
| Aparece en las colecciones: | (IBMCC) Artículos | |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| journal.pone.0013752.pdf | 931,95 kB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
16
checked on 24-abr-2024
SCOPUSTM
Citations
23
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
22
checked on 23-feb-2024
Page view(s)
378
checked on 24-abr-2024
Download(s)
316
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.